Open Access

Surgery for colorectal disease, especially that involving minimal-access techniques, continues to evolve at a fast pace. This book provides a comprehensive and current overview of some specialist areas in this field. Chapters discuss colorectal cancer, including information on anatomy, investigations, and treatment. Other topics addressed include the pathophysiology and management of benign colorectal disease, fistula-in-ano, and inflammatory bowel disease. This book is an invaluable resource for physicians, surgeons, nurses, and allied healthcare professionals.

Open Access

Breast cancer is the neoplasia with the highest incidence in the female population worldwide. Cancer originates from breast tissue, most commonly from the inner lining of milk ducts or the lobules. Histologic type, tumor grade and size, expression of ER, PR, and HER2 receptors, and lymph node and metastasis status are considered important prognostic factors. This book provides a comprehensive overview of breast cancer with chapters on breast cancer markers, breast cancer in different populations, imaging, minimally invasive techniques, breast reconstructive surgery, and much more.

For more than 40 years, DiSaia and Creasman Clinical Gynecologic Oncology has been the leading reference for diagnosis and treatment of gynecologic cancers, providing physicians and trainees alike with expert guidance on clinical presentations and management. The fully revised 10th Edition remains the most readable, most comprehensive text in the field. Under outstanding editorial leadership from Dr. William Creasman and featuring a “who’s who” list of expert contributing authors, this authoritative reference is a must-have resource for improving outcomes and providing effective patient care.
Emphasizes practical clinical presentations and management of commonly seen problems, making this text an excellent resource for daily decision making.

- Provides in-depth explanations of major topics supplemented with up-to-date references.

- Features a new chapter on Immunotherapy in Gynecologic Malignancies, updated information on invasive cervical cancer, and significantly revised content on vulvar cancer, with new guidance on micro-staging for sentinels.

- Covers key topics such as precision medicine and new biomarker-driven targeted therapies, cancer staging, targeted therapy, and immunotherapy.

- Includes quick-reference features such as key point boxes with bulleted lists, highlighted key text, enhanced chapter outlines, clinical algorithms that review recommended treatment and management options, and additional references online.

- Contains useful appendices covering staging, screening, nutritional therapy, toxicity criteria, blood component therapy, and radiation therapy.

- An ideal comprehensive resource for clinical practice, personal study, and exam review.

- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Open Access

Recent Advances, New Perspectives and Applications in the Treatment of Ovarian Cancer is a review of interesting and clinically important advances in the tumor biology and treatment of ovarian cancer. Major aspects of scientific progress in the treatment of ovarian cancer are covered, focusing on new knowledge due to advances in molecular techniques, understanding of tumor biology and innovative new treatment options. An interesting collection of innovations in the treatment of ovarian cancer and opinions from specialists in this field from around the world are brought together in this book.

Open Access

Neurorehabilitation (neuroscience-based rehabilitation) is a medical approach that utilizes the brain’s plasticity to help patients recover from nervous system injury. Remarkable progress has been made in this field, thus attracting increased attention from the scientific community. The concept of neurorehabilitation is widely accepted in physical therapy, and evaluation and treatment based on this concept are currently being practiced. This book provides a comprehensive overview of neurorehabilitation with chapters on motor imagery, repetitive peripheral magnetic stimulation, virtual reality, neurofunctional interventional approaches, and much more.

Open Access

Hepatocellular carcinoma (HCC) is a common tumor type arising from several distinct etiologies. It is usually diagnosed late and is difficult to treat. This volume presents an overview of selected aspects of HCC pathogenesis, and research aimed at developing diagnostic biomarkers. It points to a number of putative therapeutic targets, including signal transduction pathways, metabolic and epigenetic alterations in tumor cells, the tumor microenvironment, the gut microbiome, and functions of immune effector cells. Given the multi-step nature of most cancers, including HCC, future drug development will most likely require combination therapies that will simultaneously target multiple steps in hepatocarcinogenesis.

Open Access

From surgery to chemotherapy and radiotherapy, attempts to conquer colorectal cancer have been ongoing for a century. Due to these efforts, the mortality rate of colorectal cancer has decreased by about 3% per year for the past 10 years. Progress in reducing mortality from colorectal cancer can be accelerated by improving screening and the use of standard care in all populations. In recent years, advanced knowledge and technologies for better efficiency in targeting colorectal cancer have been developed to improve conventional therapeutics or to propose new therapies as standard regimens. This book discusses diagnostics as well as surgical techniques using robotics, immunotherapy, and radiology-based therapy for colorectal cancer. The section on diagnostics provides information on proteomics, organoid culture techniques, and various candidate markers. The section on treatment discusses robotic surgical techniques for rectal cancer care and multidisciplinary approaches for colorectal cancer treatment. The book also examines the latest in supportive care from a nutritional and metabolic point of view.

Open Access

Radiation Oncology provides a comprehensive overview of radiotherapy for cancer treatment. It discusses brachytherapy, external radiation, and photodynamic therapy for different types of cancers, as well as dosimetry audits, which ensure that the accurate therapeutic dose is delivered to patients undergoing radiotherapy. The need of the hour for radiotherapy procedures that provide maximum clinical care with safety and efficacy and also enhance the advantage of treatment and diminish the risks of late complications.

Open Access

Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance.

Le cancer demeure le dernier grand mystère médical. Pourtant, nous gagnons du terrain sur notre ennemi de longue date. Dans ce récit passionnant, le Dr Fung raconte l'histoire du cancer, de la façon dont il se développe aux raisons pour lesquelles un remède s'est révélé insaisissable. Il retrace l'arc de la recherche : de la focalisation myope sur la génétique, c'est-à-dire la « graine » du cancer, à notre compréhension du « sol », les conditions dans lesquelles le cancer s'épanouit. Le Dr Fung explique également le processus de la maladie et le rôle des facteurs tels que l'alimentation, l'obésité et le diabète de type 2. Enfin, il lance un appel à l'action pour une nouvelle vision

Open Access

Although it is preventable and curable, cervical cancer is the fourth most common form of cancer among women worldwide. As such, the World Health Organization adopted a Cervical Cancer Elimination Initiative, which aims to eliminate cervical cancer by 2030. This book discusses plans, programs, strategies, solutions, research, and revolutions necessary to achieve this goal. Chapters cover such topics as epidemiology, HPV vaccination, screening and treatment, and prevention and control.